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Every season new anti-aging products are launched and promoted as the new generation of slow aging. The question is “how do we know it works”? The gold standard of proof is a human clinical trial showing evidence of skin improvement however most topical ingredients have very limited research to back them up. This article looks at 4 ingredients that are commonly used in “anti-aging” products, the research that supports them and how to use them to greatest effect.

Vitamin C – Vitamin C has numerous slow aging

Natural Vitamin C

benefits: it works within the skin to promote collagen production by stimulating the genes that make collagen and stopping the enzyme that degrades it, it is an antioxidant and so reduces free-radical production in the skin, it also provides photoprotection from ultraviolet A and B, works to lighten hyperpigmentation and may also assist with the reduction of inflammation in inflammatory skin disorders.

Some great benefits however vitamin C is highly unstable in its natural form ascorbic acid and so it is advisable to only use stabilised forms such as magnesium ascorbyl phosphate or ascorbyl palmitate. Even so, vitamin C in these forms must be kept away from direct sunlight and used once opened otherwise they are prone to oxidation and stop being effective.

In addition, vitamin C absorbs into the skin very slowly and so higher concentrations are required for the above benefits. Look for products that contain 10-20% vitamin C as any less will not be effective. They also need to be acidic in form which is one of the factors that promotes an added exfoliation effect. Buffered vitamin C forms are less effective so make sur that your product has a pH of less than 3.8. If the pH and vitamin C concentration are not supplied with the product, ask your supplier before purchase to ensure you get the desired effects.

Alpha Hydroxy Acids - AHAs/PHAs will help slow aging by revitalising the topmost layer of skin. This effect is achieved by AHAs clearing dead skin cells, thinning the strata corneum thereby exposing newer skin cells, improving the quality of elastic fibres, increasing the density of collagen and stimulating the production of collagen. The net result is an anti-wrinkle effect and a reduction in signs of photoaging.

Most over the counter AHA products contain concentrations of 8-15% which promote visible results over time. However, concentrations lower than 8% do not show significant benefit and products such as cleansers and everyday moisturisers that list AHAs are unlikely to contain enough to make a significant difference.

Apple Skins contain natural fruit AHAs

The anti-wrinkle effect of AHAs is achieved by removing the top layer of dead skin cells (stratum corneum) however it also removes valuable antioxidants, particularly vitamin C and E and may also increases sun sensitivity. These side effects need to be countered by using sunscreen during the day and applying an antioxidant rich moisturiser following use of AHAs.

Due to their acidic nature AHA’s produce a tingling sensation on the skin. This effect is a sign that the product is working to exfoliate the top layers of skin. The exfoliation is gradual and results can be expected after 3 months of use. However, ongoing use of AHAs may have a mild dehydrating effect on the skin due to the potential for water loss as the strata corneum is thinned. To counter this effect, use AHAs for 2-3 months then take a break of 2-3 months.

Copper Peptides – Copper peptides emerged as a skin treatment product in the 70s when it was found to significantly stimulate skin wound healing. This end is achieved by promoting normal collagen growth rather than the abnormal collagen growth found in scar tissue. While these results were achieved with wound healing more recent use has shown that copper peptides may also have a collagen regenerating effect on normal skin. In particular, they can help repair skin after exfoliation (seen as controlled skin damage), minimise the daily assaults from sun damage and pollution and reduce skin inflammation which is significantly associated with hastening the aging process.

While copper peptides have a good safety and efficacy profile, there are some notes of caution related to using copper peptides. Again, with copper peptides, as with AHA’s more is not always better. Taking a break after 2-3 months is advisable as too much copper can have an irritating and pro-oxidant effect. In addition copper peptides are made less effective in an acidic environment so it is best to use them away from AHAs, vitamin C and retanoids.

Plant antioxidants – The most common significant finding for antioxidants of plant origin such as the catechins present in green tea, curcumin from the curry spice turmeric and apigenin present in many fruits and vegetables, is

Green Tea can reduce skin erythema

that they reduce the effects of UV damage in the skin.

For example studies using 10% green tea extract have shown that it works to minimise sun damage by reducing the production of free radicals and inflammation that result from exposure to UV rays. Apart from free radical damage, inflammation is a potential driver of premature skin ageing. Green tea would therefore be a useful addition to a sunscreen or daily moisturiser as it will provide an additional protective effective aside from the SPF factor. Please keep in mind, green tea is in no way a substitute for SPF rather it works by supporting the skins resistance to sun damage.

The unknown factor associated with the use of polyphenols and many other new topical ingredients is that unless a human clinical trial has been conducted, the concentration of the active ingredient required in the cream is unknown. Adding minute amounts of an extract to make a label claim may be beneficial from a marketing perspective but it doesn’t promote skin rejuvenation or slow skin aging.

When choosing a slow aging product for your skin, ensure that you choose those with a high enough concentration of the active ingredient where it is known and otherwise, that it is in at least the top 2/3 of the ingredient listing. Ingredients in the last 1/3 of the label listing are included in very small quantities. Alternatively, if an ingredient is touted as the active in a product then the concentration may be listed on the label. If in doubt, ask the retailer or manufacturer for this information.

Related Articles

Aging – Does Diet Make a Difference

Anti Aging Skin Care – More than just Vitamin A

The simple answer is yes. Environmental factors, nutritional status and dietary intake more than genes can add years to a person’s appearance. While topical applications make a difference, a healthy glow is more often a sign of internal health than anything else. There is a growing body of evidence to show that what we eat certainly influences skin aging and not surprisingly, the dietary correlations that relate to reduced skin aging also relate to reduced aging in general. Apart from dietary interventions, research is showing that supplementation with specific nutrients and antioxidants supports the use of topical anti-aging products and that in fact the combination is more effective than either treatment alone. Below is a review of the most significant dietary and nutritional influences on aging.

An Australian study at Monash University looked at the effects of food and nutrient intake on skin wrinkling in areas exposed to the sun. The participants were from Melbourne, Greece and Sweden.

Food intake questionnaires were used to measure diet and microphotography of the skin was used to measure skin wrinkling. The study showed that Swedish had the least skin wrinkling, followed by Greeks and Australians had the most. The types of foods consumed did have an effect on the degree of skin wrinkling with more damage seen in those with a higher intake of meat, dairy and butter. Foods that had a protective effect against skin wrinkling included vegetables, legumes, olive oil, tea, prunes and apples (see full list below). Overall, positive dietary habits trended towards a low-GI diet.

Another study supports the above food associations showing that skin wrinkling in a sun-exposed site in older people of various ethnic backgrounds may be influenced reducing intakes of fats and carbohydrates and increasing antioxidants and beneficial fats, dietary measures which are associated with better skin-aging appearance.

It is worth noting that research linking skin aging and dietary habits should not be taken out of context. Overall dietary trends produce these effects rather than any single food group in isolation. However, the dietary trends in both studies show that high GI and saturated fats seem to have the most significant pro-wrinkling effect. Due to their higher saturated fat content meat, dairy and butter can increase skin inflammation and lead to faster skin aging. In addition a high sugar intake is also associated with greater skin wrinkling. Simple sugar has a pro-inflammatory effect but it also promotes the production of advanced glycosylation end products (AGE). AGEs are closely associated with oxidative stress. A combination of a high antioxidant diet and low sugar reduces inflammation, free radical damage and AGE production in the body. Again the trend shows that the protective foods are low or have no saturated fats and are low GI and rich in phytochemicals which support skin collagen and reduce inflammation.

The Monash study indicated that these foods associated with less wrinkling:

• Mono-unsaturated fat including those from olive oil and olives
• Nuts and legumes
• Vegetables
• Fish (particularly those rich in essential fatty acids)
• Low fat milk and milk products, such as yogurt
• Wholegrain cereals
• Fruit and fruit products (especially prunes, cherries and apples)
• Eggs
• Tea and Water

More wrinkling was associated with diets that included higher intakes of:

• Saturated fat (including butter)
• Trans fats (including margarine)
• Meat (especially fatty processed meats)
• Full fat dairy products
• Refined carbohydrates and sugars such as cakes, pastries and desserts
• Soft drinks and cordials
• Confectionary of any kind
• Many packaged and processed foods contain hidden sugars
• Packaged cereals

Vegetables are the basis of a healthy diet

Apart from dietary trends, certain nutrients also show promising effects on skin aging. Studies have shown that antioxidant nutrients, specifically vitamins C and E, as well as lipoic acid and flavonoids, exert protective effect against oxidative stress in the skin, in particular photoprotective effects. That is they help protect the skin from the oxidative damage caused by the sun. Lycopene, lutein, and zeaxanthin as a specific subset of carotenoids may also be used as oral sun protectants and contribute to the maintenance of skin health. In fact, taking carotenoids prior to sun exposure will increase the depth and lasting effect of a sun tan (not that extended tanning is advised).

In other research, a daily dosage of soy isoflavones (40mg per day) resulted in the improvement of fine wrinkles and increased skin elasticity after 12 weeks of supplementation in middle-aged women with aged skin. Interestingly, a common arthritis supplement glucosamine also improved the appearance of visible wrinkles and fine lines. Glucosamine is incorporated into glucosaminoglycans (GAGs) in the body. GAGs work to increase epidermal thickness and elasticity of the skin although they have no effect on skin hydration.

A rich source of proanthocyanidins

Research into oral proanthocyanidins flavanoids from grapeseed extract or pycnogenol has shown they both have a significant protective effect on the collagen matrix of the skin and capillaries. They work by reducing capillary fragility and inhibiting collagen, hyaluronic acid and elastin breakdown. Both substances also have an anti-inflammatory effect and can improve peripheral circulation.

Again it is important to note that while supplemental nutrition can support skin health in a number of ways, if concurrent dietary changes aren’t made, the supplements will be combating the constant inflammatory cascade from high GI foods and saturated fats. Removing these dietary items will ensure that inflammation, AGEs and oxidation are all reduced allowing the supplements to work to their optimal level and effect real changes in skin health.

Author: Ananda Mahony ND. Ananda is a naturopath and skin specialist. She owns Vitale Natural, an organic skin care store and beauty salon in Paddington, Brisbane. www.vitalenatural.com.au